Long peptide-based cancer immunotherapy targeting tumor antigen-specific CD4+ and CD8+ T cells
نویسندگان
چکیده
CD4+ T cells promote cytotoxic T lymphocyte (CTL)-mediated anticancer immune responses. We have recently identified ideal tumor-associated antigen (TAA)-derived long peptides (LPs) that elicit not only TAA-specific TH1 response, but also CTLs, through cross-presentation. The LP-specific TH1 cell responses were augmented in cancer patients vaccinated with CTL epitopes. Our findings support the clinical application of LP-based immunotherapy.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013